view in publisher's site

Multiscale model within-host and between-host for viral infectious diseases

Multiscale models possess the potential to uncover new insights into infectious diseases. Here, a rigorous stability analysis of a multiscale model within-host and between-host is presented. The within-host model describes viral replication and the respective immune response while disease transmission is represented by a susceptible-infected model. The bridging of scales from within- to between-host considered transmission as a function of the viral load. Consequently, stability and bifurcation analyses were developed coupling the two basic reproduction numbers \(R_0^{W}\) and \(R_0^{B}\) for the within- and the between-host subsystems, respectively. Local stability results for each subsystem, including a unique stable equilibrium point, recapitulate classical approaches to infection and epidemic control. Using a Lyapunov function, global stability of the between-host system was obtained. Our main result was the derivation of the \(R_0^{B}\) as an increasing function of \(R_0^{W}\). Numerical analyses reveal that a Michaelis–Menten form based on the virus is more likely to recapitulate the behavior between the scales than a form directly proportional to the virus. Our work contributes basic understandings of the two models and casts light on the potential effects of the coupling function on linking the two scales.

مدل Multiscale درون میزبان و بین میزبان برای بیماری‌های عفونی ویروسی

ترجمه شده با


پر ارجاع‌ترین مقالات مرتبط:

  • مقاله Applied Mathematics
  • ترجمه مقاله Applied Mathematics
  • مقاله ریاضیات کاربردی
  • ترجمه مقاله ریاضیات کاربردی
  • مقاله Modelling and Simulation
  • ترجمه مقاله Modelling and Simulation
  • مقاله مدل‌سازی و شبیه‌سازی
  • ترجمه مقاله مدل‌سازی و شبیه‌سازی
  • مقاله Agricultural and Biological Sciences (miscellaneous)
  • ترجمه مقاله Agricultural and Biological Sciences (miscellaneous)
  • مقاله علوم کشاورزی و زیستی (متفرقه)
  • ترجمه مقاله علوم کشاورزی و زیستی (متفرقه)
سفارش ترجمه مقاله و کتاب - شروع کنید

95/12/18 - با استفاده از افزونه دانلود فایرفاکس و کروم٬ چکیده مقالات به صورت خودکار تشخیص داده شده و دکمه دانلود فری‌پیپر در صفحه چکیده نمایش داده می شود.