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Obesity and aging: Molecular mechanisms and therapeutic approaches

Highlights•Obesity is a major public health problem.•The metabolic dysregulation associated with obesity is remarkably similar to that observed in normal aging.•Substantial evidence suggests the potential of obesity to accelerate aging.•Understanding the molecular mechanisms of obesity can provide insights into the aging process.•Lifestyle and pharmacological interventions to manage obesity can also be useful in mitigating the aging process.AbstractThe epidemic of obesity is a major challenge for health policymakers due to its far-reaching effects on population health and potentially overwhelming financial burden on healthcare systems. Obesity is associated with an increased risk of developing acute and chronic diseases, including hypertension, stroke, myocardial infarction, cardiovascular disease, diabetes, and cancer. Interestingly, the metabolic dysregulation associated with obesity is similar to that observed in normal aging, and substantial evidence suggests the potential of obesity to accelerate aging. Therefore, understanding the mechanism of fat tissue dysfunction in obesity could provide insights into the processes that contribute to the metabolic dysfunction associated with the aging process.Here, we review the molecular and cellular mechanisms underlying both obesity and aging, and how obesity and aging can predispose individuals to chronic health complications. The potential of lifestyle and pharmacological interventions to counter obesity and obesity-related pathologies, as well as aging, is also addressed.


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