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Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review

Crit Rev Oncol Hematol. 2018 Feb;122:30-51. doi: 10.1016/j.critrevonc.2017.12.005. Epub 2017 Dec 14.Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review.Mohajeri M1, Sahebkar A2.Author information1Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.2Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected] (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic approaches. Despite effective in the treatment of numerous malignancies, some clinicians have voiced concern that DOX has the potential to cause debilitating consequences in organ tissues, especially the heart. The mechanisms of toxicity and resistance are respectively related to induction of reactive oxygen species (ROS) and up-regulation of ATP-binding cassette (ABC) transporter. Curcumin (CUR) with several biological and pharmacological properties is expected to restore DOX-mediated impairments to tissues. This review is intended to address the current knowledge on DOX adverse effects and CUR protective actions in the heart, kidneys, liver, brain, and reproductive organs. Coadministration of CUR and DOX is capable of ameliorating DOX toxicity pertained to antioxidant, apoptosis, autophagy, and mitochondrial permeability.Copyright © 2017 Elsevier B.V. All rights reserved.KEYWORDS: ABC transporters; Curcumin; Doxorubicin; Oxidative stress; Resistance; ToxicityPMID: 29458788 DOI: 10.1016/j.critrevonc.2017.12.005 [Indexed for MEDLINE] SharePublication type, MeSH terms, SubstancesPublication typeReviewMeSH termsAnimalsAntibiotics, Antineoplastic/adverse effectsApoptosis/drug effectsAutophagy/drug effectsCurcumin/pharmacology*Doxorubicin/adverse effects*Drug InteractionsDrug Resistance, NeoplasmHumansNeoplasms/drug therapyNeoplasms/pathologySubstancesAntibiotics, AntineoplasticDoxorubicinCurcuminLinkOut - more resourcesFull Text SourcesElsevier ScienceClinicalKeyMiscellaneousDOXORUBICIN - Hazardous Substances Data BankCURCUMIN - Hazardous Substances Data Bank

اثرات جانبی of علیه سمیت و مقاومت القا شده توسط دوکسوروبیسین: بازبینی. بازبینی بحرانی در Oncology / Hematology، ۱۲۲، ۳۰ - ۵۱

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