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Prevalence of human papilloma virus and Epstein–Barr virus in tumorous and adjacent tissues of colorectal cancer in Iran

Highlights•Our data highlighted the presence of HPV DNA in 13 samples. Among them 4 samples were belonged to control group and 9 samples were of patients suffering from CRC.•None of our samples were EBV positive.•We suggested that HPV could be considered as a plausible risk factor for the incidence of colorectal cancerAbstractBackgroundMultiple risk factors have been involved in the pathogenesis of colorectal cancer (CRC), in which the significant role of viral infections could not be underestimated. Despite endorsed attempts to identify the accelerating effects of human papilloma virus (HPV) and Epstein–Barr virus (EBV) on the progression of different solid and hematologic malignancies, the association between these viruses and CRC has not successfully been recognized. Taking advantages of these facts, it was attempted to evaluate the association between the prevalence of these viruses and the incidence of CRC.MethodsIn this case-control study, we collected 74 tumorous and 63 their adjacent paraffin-embedded tissues from Modares Hospital between 2011 and 2019. DNA from each tissue was extracted and the presence of HPV and EBV was investigated using Nested PCR and PCR, respectively.ResultsOur data highlighted the presence of HPV DNA in 13 samples. Among them 4 samples belonged to control group and 9 samples were of patients suffering from CRC at different disease stages; however, none of our samples were EBV positive, and we failed to find an obvious correlation between EBV infection and this type of cancer. Phylogenic analysis revealed that among different strains of HPV, HPV18 was particularly common in all chosen patients, introducing it as a probable risk factor for the progression of colorectal cancer. Moreover, it seems that HPV infection could participate in the pathogenesis of this cancer independent of either age or sex.ConclusionsWe suggested that HPV could be considered as a plausible risk factor for the incidence of colorectal cancer; however, further investigations are warranted to provide valuable clues to add this virus as hallmarks of CRC.

فراوانی ویروس پاپیلومای انسانی و ویروس اپستین - بار در بافت‌های توموری و مجاور سرطان روده بزرگ در ایران

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