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Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents

Highlights•Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes•Syntheses, characterization and X-ray crystallography•Screening antiproliferative effect towards 4 human tumor cell lines•High cytotoxic activity against ovarian and colorectal carcinoma cellsAbstractA series of four mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes [CuL(X)]2 [L refers to the dianionic form of (5-bromo-2-hydroxybenzylidene)-2-hydroxybenzohydrazide; X = pyrazine (Pz; 1), pyridine (Py; 2), imidazole (Imz; 3) and 3-pyridinecarbonitrile (3-PyCN; 4)] has been synthesized and characterized by elemental analysis, various spectroscopic techniques and X-ray crystallography (for 1, 2 and 4). The antiproliferative effect of complexes 1–4 was examined in 4 human tumor cell lines (ovarian carcinoma (A2780), colorectal carcinoma (HCT116), lung adenocarcinoma (A549) and breast adenocarcinoma (MCF7)) and in normal human primary Fibroblasts. Complex 4 exhibits a high cytotoxic activity against ovarian and colorectal carcinoma cells (A2780, HCT116 respectively), with IC50 much lower than those for normal primary fibroblasts. Complex 4 could induce cell death via apoptosis but not autophagy in colorectal carcinoma cells.Graphical abstractFour mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes have been synthesized and characterized. Their antiproliferative effect was screened towards 4 human tumor cell lines. One of them exhibited high cytotoxic activity against ovarian and colorectal carcinoma cells.Download : Download high-res image (122KB)Download : Download full-size image

لیگاند مختلط لیگاند های ترکیبی N و N - donor (II)complexes (II)به عنوان عوامل بالقوه antiproliferative

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