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Mn(II) based T1 and T2 potential MRI contrast agent appended with tryptamine: Recognition moiety for Aβ-plaques

Highlights•Manganese complexes derived from pentadentate ligands were synthesized.•Molecular structures were authenticated by X-ray crystallographic studies.•Manganese based contrast agent was utilized for Magnetic Resonance Imaging.•Pendant tryptamine, attached to complex exhibited affinity towards Amyloid Beta-fibrils.AbstractWe report the synthesis and characterization of manganese(II) complexes having pentadentate ligands L1 (2,6-bis(1-(2-phenyl-2-(pyridin-2-yl)hydrazono)ethyl)pyridine), L2 (methyl 2,6-bis((E)-1-(2-phenyl-2-(pyridin-2yl)hydrazono)ethyl)isonicotinate), L3 (N-(2-(1H-indol-3-yl)ethyl)-2,6-bis((E)-1-(2-phenyl-2-(pyridin2yl)hydrazono)ethyl)isonicotiamide) and their application as dual contrast agents for simultaneous T1 and T2 weighted magnetic resonance imaging. Single crystal analysis of all the complexes [MnIIL1, MnIIL2 and MnIIL3] confirm the formation of novel seven-coordinate manganese complexes with an inner sphere water and perchlorate ion. The Magnetic Resonance Imaging (MRI) contrast agent [MnL2] was further modified by incorporating tryptamine as a binding moiety specific to Amyloid Beta-fibrils (Aβ-fibrils) in Alzhiemer's disease (AD) and it's in vitro evaluation for specific binding with Aβ-fibrils indicated as a bio-marker of AD.Graphical abstractMn(II)-based small molecule as dual Magnetic Resonance Imaging (MRI) contrast agent appended with tryptamine for effective in vitro binding with Amyloid Beta-fibrils (Aβ-fibril), a biomarker for Alzheimer disease.Download high-res image (187KB)Download full-size image

Mn (II)مبتنی بر T۱ و T۲ عامل کنتراست MRI را با tryptamine الحاق کرد: شناسایی بخش برای پلاک‌های -

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95/12/18 - با استفاده از افزونه دانلود فایرفاکس و کروم٬ چکیده مقالات به صورت خودکار تشخیص داده شده و دکمه دانلود فری‌پیپر در صفحه چکیده نمایش داده می شود.