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Layer-by-layer immobilizing of polydopamine-assisted ε-polylysine and gum Arabic on titanium: Tailoring of antibacterial and osteogenic properties

Highlights•Multilayer composite films of ε-PL and GA were constructed on TNTs by both covalent grafting and LBL for the first time.•Concurrently improved antibacterial and osteogenic properties were achieved on ε-PL and GA multilayer composite films.•Long term antibacterial properties against both gram-positive and gram-negative bacterial were obtained up to three weeks.•The LBL composite films are promising to accepted in clinical application due to high biosafety grade of ε-PL and GA.AbstractBacterial infection has become a crucial reason that give rise to failure of medical implants in clinical applications. In this regard, various antibacterial surface modifications of implants have been developed in recent years. However, it remains a challenge to enable the implant surfaces with both suitable antibacterial and osteogenic properties. In this work, ε-polylysine and gum Arabic multilayer composite films were immobilized layer by layer (LBL) on anodized titanium with the assistance of polydopamine for the first time. In vitro antibacterial results showed that the bacteria numbers decreased with an increase in the loading amount of ε-polylysine. Furthermore, long-term antibacterial property up to 3 weeks against both gram-positive Staphylococcus aureus (S. aureus) and gram-negative Escherichia coli (E. coli) was obtained combined with the merits of covalent binding and LBL methods. Meanwhile, the cell proliferation and osteogenic differentiation of BMSCs on titanium dioxide nanotubes (TNTs) modified with composite films was significantly improved. Remarkably, a facile method to optimize anti-infective and osteogenic properties of medical titanium has been developed, and it was demonstrated that the ε-polylysine and gum Arabic multilayer composite films with assistance of polydopamine were able to endow the orthopedic implant materials both improved antibacterial property and excellent biocompatibility, which is of profound significance for practical application of titanium-based implants.Graphical abstractDownload : Download high-res image (359KB)Download : Download full-size image

لایه لایه - لایه با استفاده از ε - polylysine و gum عربی در تیتانیوم: tailoring از خواص ضد میکروبی و ضد میکروبی

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