view in publisher's site

Temperament traits moderate the relationship between Childhood Trauma and Interleukin 1β profile in young adults

Highlights•IL-1β levels were increased in young adults with a history of childhood trauma (CT).•Temperaments anger and sensitivity increased in response to CT severity.•Anger, volition and sensitivity moderated the impact of CT on IL-1β levels.•The moderating effect of anger was stronger in men.AbstractEarly life stressors, such as childhood trauma, have been associated to alterations in immune response that can last until adulthood. In this context, interleukin 1β (IL-1β) emerges as a pro-inflammatory cytokine with a pivotal role. Also, considering the temperament differences in stress susceptibility, and even immune dysfunction, studies investigating the complex interaction between these factors are scarce. Thus, the aim of the present study was to evaluate the moderating role of temperament traits in the relationship between childhood trauma and serum IL-1β levels. This cross-sectional study consisted of 325 individuals, men and women, aged 18-35, enrolled from a population-based study in the city of Pelotas, Southern Brazil. Our main results indicate that higher serum levels of IL-1β were associated with trauma severity (p < 0.01), and the variance of anger could explain 29% of IL-1β increase in individuals who suffered severe trauma (p < 0.05). The effect of anger was considerably stronger in men than in women (46% and 25%, respectively). Moreover, the variance of sensitivity also explained 15% of IL-1β increase (p < 0.05) as well as the variance of volition explained 11% of IL-1β decrease (p < 0.05) in individuals who suffered severe trauma in the general population. Our results indicate that emotional individual differences can moderate the impact of childhood trauma on low-grade inflammation in young adults.

صفات برجسته، رابطه بین آسیب دوران کودکی و پروفایل Interleukin ۱ در بزرگسالان جوان را تعدیل می‌کنند.

ترجمه شده با


پر ارجاع‌ترین مقالات مرتبط:

  • مقاله Psychiatry and Mental health
  • ترجمه مقاله Psychiatry and Mental health
  • مقاله روان‌پزشکی و سلامت روان
  • ترجمه مقاله روان‌پزشکی و سلامت روان
  • مقاله Biological Psychiatry
  • ترجمه مقاله Biological Psychiatry
  • مقاله روان‌پزشکی زیستی
  • ترجمه مقاله روان‌پزشکی زیستی
  • مقاله Endocrinology, Diabetes and Metabolism
  • ترجمه مقاله Endocrinology, Diabetes and Metabolism
  • مقاله درون‌ریزشناسی، دیابت و متابولیسم
  • ترجمه مقاله درون‌ریزشناسی، دیابت و متابولیسم
  • مقاله Endocrinology
  • ترجمه مقاله Endocrinology
  • مقاله درون‌ریزشناسی
  • ترجمه مقاله درون‌ریزشناسی
  • مقاله Endocrine and Autonomic Systems
  • ترجمه مقاله Endocrine and Autonomic Systems
  • مقاله سیستم‌های درون‌ریز و خودمختار
  • ترجمه مقاله سیستم‌های درون‌ریز و خودمختار
سفارش ترجمه مقاله و کتاب - شروع کنید

با استفاده از افزونه دانلود فایرفاکس چکیده مقالات به صورت خودکار تشخیص داده شده و دکمه دانلود فری‌پیپر در صفحه چکیده نمایش داده می شود.