view in publisher's site

Escherichia coli as a host for metabolic engineering

Highlights•The well characterized physiology of E. coli allows for rapid strain development.•A plethora of genetic techniques have been developed for genomic edits in E. coli including the λ-Red recombinase system, CRISPR, and MAGE.•A wide variety of chemicals have been produced by E. coli both in the laboratory and for industrial scale production.AbstractOver the past century, Escherichia coli has become one of the best studied organisms on earth. Features such as genetic tractability, favorable growth conditions, well characterized biochemistry and physiology, and availability of versatile genetic manipulation tools make E. coli an ideal platform host for development of industrially viable productions. In this review, we discuss the physiological attributes of E. coli that are most relevant for metabolic engineering, as well as emerging techniques that enable efficient phenotype construction. Further, we summarize the large number of native and non-native products that have been synthesized by E. coli, and address some of the future challenges in broadening substrate range and fighting phage infection.


پر ارجاع‌ترین مقالات مرتبط:

  • مقاله Bioengineering
  • ترجمه مقاله Bioengineering
  • مقاله مهندسی زیستی
  • ترجمه مقاله مهندسی زیستی
  • مقاله Applied Microbiology and Biotechnology
  • ترجمه مقاله Applied Microbiology and Biotechnology
  • مقاله میکروبیولوژی و بیوتکنولوژی کاربردی
  • ترجمه مقاله میکروبیولوژی و بیوتکنولوژی کاربردی
  • مقاله Biotechnology
  • ترجمه مقاله Biotechnology
  • مقاله بیوتکنولوژی
  • ترجمه مقاله بیوتکنولوژی
سفارش ترجمه مقاله و کتاب - شروع کنید

95/12/18 - با استفاده از افزونه دانلود فایرفاکس و کروم٬ چکیده مقالات به صورت خودکار تشخیص داده شده و دکمه دانلود فری‌پیپر در صفحه چکیده نمایش داده می شود.