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Whole-Body Distribution and Radiation Dosimetry of68Ga-NOTA-RGD, a Positron Emission Tomography Agent for Angiogenesis Imaging

Cancer Biother Radiopharm. 2012 Feb;27(1):65-71. doi: 10.1089/cbr.2011.1061. Epub 2011 Dec 9.Whole-body distribution and radiation dosimetry of (68)Ga-NOTA-RGD, a positron emission tomography agent for angiogenesis imaging.Kim JH1, Lee JS, Kang KW, Lee HY, Han SW, Kim TY, Lee YS, Jeong JM, Lee DS.Author information1Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.Abstract(68)Ga labeled NOTA-RGD was a recently developed positron emission tomography (PET) radiotracer for the visualization of angiogenesis, and is regarded as a promising imaging agent for cancer and several other disorders. In this study, we investigated the whole-body distribution and radiation dosimetry of (68)Ga-NOTA-RGD in humans. Ten cancer patients (53.7 ± 13.5 years; 61.5 ± 7.4  kg) participated in this study. PET scans were performed using a PET/computed tomography (scanner in three-dimensional mode). After an intravenous injection of 172.4 ± 20.5  MBq of (68)Ga-NOTA-RGD, eight serial whole-body scans were performed during 90 minutes. Volumes of interest were drawn manually over the entire volumes of the urinary bladder, the gallbladder, heart, kidneys, liver, lungs, pancreas, spleen, and stomach. Time-activity curves were obtained from serial PET scan data. Residence times were calculated from areas under curve of time-activity curves and used as input to the OLINDA/EXM 1.1 software. The uptake of (68)Ga-NOTA-RGD was highest in the kidneys and urinary bladder. Radiation doses to kidneys and urinary bladder were 71.6 ± 28.4  μ Gy/MBq and 239.6 ± 56.6  μ Gy/MBq. Mean effective doses were 25.0 ± 4.4  μ Sv/MBq using International Commission of Radiation Protection (ICRP) publication 60 and 22.4 ± 3.8  μ Sv/MBq using ICRP publication 103 weighting factor. We evaluated the radiation dosimetry of (68)Ga labeled NOTA-RGD, which has an acceptable effective radiation dose.PMID: 22149685 DOI: 10.1089/cbr.2011.1061 [Indexed for MEDLINE] SharePublication type, MeSH terms, SubstancesPublication typeResearch Support, Non-U.S. Gov'tMeSH termsAdultAgedFemaleGallium Radioisotopes/analysisGallium Radioisotopes/pharmacokinetics*Heterocyclic Compounds/pharmacokineticsHumansLung Neoplasms/blood supply*Lung Neoplasms/metabolismLymphoma/metabolism*MaleMiddle AgedNeovascularization, Pathologic/diagnostic imaging*Oligopeptides/pharmacokineticsPositron-Emission Tomography/methodsRadiation DosageRadiometry/methodsRadiopharmaceuticals/analysisRadiopharmaceuticals/pharmacokinetics*Tissue DistributionSubstancesGallium RadioisotopesHeterocyclic CompoundsOligopeptidesRadiopharmaceuticals1,4,7-triazacyclononane-N,N',N''-triacetic acidarginyl-glycyl-aspartic acidLinkOut - more resourcesFull Text SourcesAtypon - PDFMedicalLymphoma - MedlinePlus Health InformationLung Cancer - MedlinePlus Health InformationMiscellaneousNCI CPTC Antibody Characterization Program

Tomography توزیع کامل بدن و Radiation Radiation از ۶۸ Ga - آر جی آر جی، یک پوزیترون برای عکاس Angiogenesis Tomography. سرطان Biotherapy و radiopharmaceuticals، ۲۷ (۱)، ۶۵ - ۷۱

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