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Two-year dynamic functional network connectivity in clinically isolated syndrome

Mult Scler. 2019 Mar 19:1352458519837704. doi: 10.1177/1352458519837704. [Epub ahead of print]Two-year dynamic functional network connectivity in clinically isolated syndrome.Rocca MA1, Hidalgo de La Cruz M2, Valsasina P2, Mesaros S3, Martinovic V3, Ivanovic J3, Drulovic J3, Filippi M1.Author information1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.2Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.3Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.AbstractBACKGROUND:: The features of functional network connectivity reorganization at the earliest stages of MS have not been investigated yet.OBJECTIVE:: To combine static and dynamic analysis of resting state (RS) functional connectivity (FC) to identify mechanisms of clinical dysfunction and recovery occurring in clinically isolated syndrome (CIS) patients.METHODS:: RS functional magnetic resonance imaging (fMRI) and clinical data were prospectively acquired from 50 CIS patients and 13 healthy controls (HC) at baseline, month 12 and month 24. Between-group differences and longitudinal evolution of network FC were analysed across 41 functionally relevant networks.RESULTS:: At follow-up, 47 patients developed MS. Disability remained stable (and relatively low). CIS and HC exhibited two recurring RS FC states (states 1 and 2, showing low and high internetwork connectivity, respectively). At baseline, patients showed reduced state 2 connectivity strength in the default-mode and cerebellar networks, and no differences in global dynamism versus HC. A selective FC reduction in networks affected by the clinical attack was also detected. At follow-up, increased state 2 connectivity strength and global connectivity dynamism was observed in patients versus HC.CONCLUSION:: Longitudinal FC modifications occurring relatively early in the course of multiple sclerosis may represent a protective mechanism contributing to preserve clinical function over time.KEYWORDS: Multiple sclerosis; clinically isolated syndrome; default-mode network; dynamic functional network connectivity; longitudinal; resting statePMID: 30887875 DOI: 10.1177/1352458519837704 ShareLinkOut - more resourcesFull Text SourcesAtypon

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